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How Is Restless Legs Syndrome Treated?

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By Editorial Team

4 min read

Reviewed by: HU Medical Review Board | Last reviewed: May 2025 | Last updated: May 2025

Restless legs syndrome (RLS) is one of the most common sleep disorders. It causes unpleasant sensations in the legs and the irresistible urge to move the legs. People describe these sensations as aching, throbbing, itching, pulling, twitching, or tingling. This can even affect the arms. There are many ways to treat RLS.1,2

If you have RLS, the type of treatment you will receive depends on what your doctor believes is the underlying cause. The basic types of treatments for RLS are:1-8

  • Lifestyle changes, including better sleep habits
  • Iron supplements if you are iron deficient
  • Prescription drugs
  • Devices
  • Home remedies

Lifestyle changes for restless legs syndrome

Many people find that simple lifestyle changes improve their symptoms of RLS. It may take some trial and error to find the combination of lifestyle changes that works for you.

Regular exercise, such as walking or yoga, helps many people. Others find that reducing or cutting out caffeine, alcohol, or smoking helps. If you work in an office, asking to stand more often or do your job at a standing desk can help relieve daytime leg sensations.8

People with RLS often find that their symptoms get worse when they have not been getting enough sleep or if they have an untreated sleep disorder such as obstructive sleep apnea. Making sure to set aside enough time for sleep every night helps many people with RLS.8

Certain drugs can trigger RLS, such as antihistamines, anti-nausea medicines, and some antidepressants. Your doctor may be able to prescribe a different medicine that does not aggravate your RLS.1-3

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Iron supplements for restless legs syndrome

Many people with RLS have low iron levels in their blood or brain. Because of this, taking iron pills sometimes helps relieve the symptoms of RLS.1,2

Iron supplements can cause side effects, including an upset stomach and constipation, so not everyone can take iron. Eating more red meat, lentils, spinach, and other foods high in iron may help too. Due to the dangers of iron overload and iron’s side effects, you should take iron only with a doctor’s supervision.1,7,8

Prescription drugs for restless legs syndrome

If RLS occurs nearly every night and causes serious issues with your quality of life, your doctor may suggest a prescription drug. These drugs include:8

  • Alpha-2-delta calcium channel ligands (gabapentin enacarbil, pregabalin, and gabapentin)
  • Iron, including IV iron
  • Opioids

All of these drugs may have side effects. They also may lose their effect for you over time. When RLS symptoms get worse even when taking higher doses, it is called augmentation.8

Augmentation may be difficult to treat. Some of the older drugs for RLS were highly effective but caused augmentation and are no longer recommended as first-line treatment. For those who are already on these medicines, do not stop them without discussing it with your healthcare professional, as they may still be effective for you.8

Devices for restless legs syndrome

A few devices may be used to treat RLS. Restiffic foot wraps are approved by the US Food and Drug Administration (FDA) to treat RLS. The newest device to treat RLS is Nidra from Noctrix. It is a band that you wear on your calves and stimulates your muscles to provide similar relief as walking. They both require a prescription from your doctor.9

Many other devices are sold online and provide pressure or vibration to the legs. Some of these devices have been studied and found to help with RLS, while others have not. Costs range from $20 to $2,500.5

Home remedies for restless legs syndrome

People reach for a wide variety of home remedies when it comes to finding relief from RLS symptoms. These include:7

  • Stretching
  • Walking
  • Hot or cold packs
  • Massage
  • Magnesium, vitamin D, B9, or B12 supplements
  • Evening bath or shower
  • Weighted blankets
  • Relaxing creams and oils
  • Avoiding tobacco, caffeine, alcohol, dairy, or sugar before bed
  • Bar of soap under the fitted sheet

Any stretching or exercise before bedtime should be gentle. Vigorous exercise stimulates the system rather than relaxing it. Some people with RLS distract themselves from the leg sensations until sleep comes on. For example, you can distract yourself with:7,10

  • Crossword puzzles
  • Knitting
  • Reading

Most home remedies carry low or no risk of causing another health problem and are affordable. However, it is always a good idea to talk with your doctor or pharmacist before taking any new supplements.

Treating secondary restless legs syndrome

There are 2 types of RLS, primary and secondary. Doctors believe primary RLS is caused by a combination of genetics and the environment. Sometimes, though, RLS is caused by another health condition. In these cases, called secondary RLS, treating the underlying cause of RLS relieves symptoms. The following conditions are known to cause RLS in some people:1-3

  • Anemia, caused by low iron levels
  • Pregnancy
  • End-stage kidney disease
  • Diabetes
  • Multiple sclerosis
  • Rheumatoid arthritis
  • Parkinson’s disease
  • Peripheral neuropathy
  • Heart disease
  • COPD (chronic obstructive pulmonary disease)
  • Spinal cord injuries

About 1 in 4 pregnant people develop RLS, usually in the third trimester. It often disappears in the weeks after birth.1-3

Treatment results and side effects can vary from person to person. This treatment information is not meant to replace professional medical advice. Talk to your doctor about what to expect before starting and while taking any treatment.