I use Jobst "knee high" "open toe" compression socks to relieve my symptoms . When the first symptom occurs in either one or both legs, I put on my Jobst compression socks and relief occurs immediately or within 1-3 minutes.... every time. I use no medication for RLS, just the compression socks. I've been using them for the past 10 years and this is an easy solution to a frustrating problem. I hope you have the same results.