I have had rls every night for the past fifteen years. My first experience with rls was during my pregnancy with son and it was full blown rls which thankfully disappeared when I gave birth. I was 36. Never returned until I was 50 yrs old when I reached menopause. I have had it every night since and I am now 65. Now one might think this is hormonal or iron deficiency, however, ferritin levels are normal and also have tried supplementing iron and magnesium to no avail. Have not tried the glycinate yet. The other family members I am aware of that suffer from this are men. It always affects me in the pelvic area at the top other leg, usually one at a time. When it goes away in one leg, it moves to the opposite leg. This can go on all night. On rare occasions I will get it in the arms. And yes, the frustration can get so bad. I have been on ropinerole all this time with some success, but doesn't last all night so it is just a game. You all know. Get up, lay down. Get up, lay down, etc. I have tried every exercise and position one can imagine. Yoga helps temporarily, and a hot bath also works, temporarily. It is a lonely disease. A person probably really can't understand it unless they have it. I think we need more professionals that actually suffer from this.