Hi . Your post inspired me to do a bit of research and I found this article: https://pmc.ncbi.nlm.nih.gov/articles/PMC3601318/. It seems the iron deficiency caused by multiple myeloma can triggered RLS. RLS can have many causes, which is one reason it's hard to treat. Here is an article about the potential causes that might interest you: https://restlesslegssyndrome.sleep-disorders.net/causes. Have you been diagnosed with multiple myeloma or do you suspect you have it? Wishing you the best. - Lori (Team Member)